[BioC] sequence search using a position weight matrix?
Paul Shannon
pshannon at systemsbiology.org
Tue Oct 9 14:38:51 CEST 2007
Does any bioc package support amino acid sequence search using a pre-
defined
position weight matrix (pwm)?
As best I can tell, Biostrings, for all of its capabilities, does not
support
sequence matching using pwm's. cosmo (again, as best I can tell)
does not
accept a pwm as input; rather, it identifies pwm's from the input
sequences.
I'd be delighted to find out I am wrong on one or both counts ... or
to hear
of another bioc package that does sequence search with pwm's.
For background: I obtain position weight matrices which predict
kinase substrates from Predikin (http://predikin.biosci.uq.edu.au/
pkr/). I wish
to use these matrices to search for possible kinase substrates in
peptide sequences
obtained from mass spectrometry.
Many thanks --
- Paul
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