[BioC] Workflow question in lumi

[Longsi Ran]

Hi,

I noticed that your recommended Illumina workflow in lumi is: 1. VST 
transformation (including Logarithm).  2, RSN or Quantile normalization.  As 
most of normalization work on linear expression values, is there a 
particular logic to establish normalizing only logged data?  In other words, 
Logarithm first, then Normalization, or vice versa?

I am looking forward to hearing from you soon.

Thanks!

Longsi Ran M.D

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