[BioC] output of coxfilter function in genefilter package

[James W. MacDonald]

carol white wrote:
> Hi, I have fitted a univariate cox regression a data set and retained
> the genes whose p-value were less or equal to 0.05. the total number
> of retained genes is 2746. I also filtered genes based on the same
> condition (pval <= 0.05) on the same data set using coxfilter
> function in genefilter package and got  2648 genes, i.e 98 genes less
> than the number of genes that I got by univariate cox model. Should I
> have not got the same number of genes?

Not necessarily. It depends on what p-value you are using. The coxfilter 
function uses the likelihood ratio to compute a p-value. If you are 
using a Wald or Score test, the p-value may be different enough for some 
genes that they would pass your p-value filter, but not for the p-value 
returned from coxfilter.

> 
> Moreover, I think the output of coxfilter is just a set of genes
> whose pval <= a threshold like 0.05 and it doesn't provide a gene set
> based on p-val ranking (ascending or descending) which I need.

You are correct - coxfilter is designed to give TRUE/FALSE indices to 
filter your genes.. However, it wouldn't take much to change coxfilter 
to simply return the p-values (or alternatively for you to emulate 
coxfilter with your own function that will do what you want).

Best,

Jim


> 
> regards, carol
> 
> 
> ---------------------------------
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-- 
James W. MacDonald, M.S.
Biostatistician
Affymetrix and cDNA Microarray Core
University of Michigan Cancer Center
1500 E. Medical Center Drive
7410 CCGC
Ann Arbor MI 48109
734-647-5623


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