[BioC] different density
kubamieczkowski at op.pl
Mon Dec 17 23:28:37 CET 2007
I'm new to Bioconductor and I want to analyse time course data (6 time
points, 3 oligo arrays in each). During the quality control (QCReport) I
found that 4 arrays have different densities. What is shown here:
Plot of NUSE shows differences too. Images of weights are a little bit
different form rest, but I can't notice any artefacts.
3 of them, are from the same time point.
Should I remove them from further analysis (differences can have
biological basis)? Or maybe I just can't use methods like RMA (because
of different distributions)? Do you have any suggestions?
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