[BioC] different density

Jakub Mieczkowski kubamieczkowski at op.pl
Mon Dec 17 23:28:37 CET 2007

Hi All,
I'm new to Bioconductor and I want to analyse time course data (6 time
points, 3 oligo arrays in each). During the quality control (QCReport) I
found that 4 arrays have different densities. What is shown here:


Plot of NUSE shows differences too. Images of weights are a little bit 
different form rest, but I can't notice any artefacts.
3 of them, are from the same time point.

Should I remove them from further analysis (differences can have 
biological basis)? Or maybe I just can't use methods like RMA (because 
of different distributions)? Do you have any suggestions?

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