[BioC] Z factor and Z' factor

[ligia at ebi.ac.uk]

Hi Steve,

The difference is that the Z-factor assesses the screening assay quality
using the distribution of the control values (either positive or negative
controls, depending on the type of the assay) and the samples, while the
Z'-factor is based exclusively on controls data using both positive and
negative controls.
You can find more details in the reference below:

JH Zhang, TD Chung, and KR Oldenburg. A Simple Statistical Parameter
for Use in Evaluation and Validation of High Throughput Screening
Assays. J Biomol Screen, 4(2):67–73, 1999.

Cheers,
Ligia


> Hi,
>
> Please can someone explain what is the difference between Z-factor and
> Z'-factor as reported in cellHTS2?
>
> Many Thanks,
>
> Steve
>
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