[BioC] Duplicated probesets for the same gene
smohapat at vbi.vt.edu
Mon Apr 24 00:02:44 CEST 2006
I have a small curiosity regarding annotation of probesets in affy GeneChips. I find that some times 2 probe sets refer to the same gene.
For example, in the HG_U95Av2, there are 2 probesets (1369_s_at and 35372_r_at) both point to the same gene IL8. I wonder what is the scientific reason for such a duplication?
I understand that the signal from 2 probesets would be affected by dye-labeling effect and hybridization effect in addition to mRNA abundance. What is then the point of having 2 probe sets which might give different results for the same gene?
Please send any pointers/references that you find appropriate.
Thanks for your consideration.
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