[BioC] SAM q-values

Holger Schwender holger.schw at gmx.de
Wed Mar 31 10:56:20 CEST 2004


Hi Makis,

the q-values are computed as described in John Storey's and Rob Tibshirani's
paper "Statistical significance for genome-wide studies." 

HTH,
Holger

> Dear all,
> 
> I perfomred SAM analysis in my dataset and the sam.plot command that gave 
> me estimates of the q-values for the significant genes. However all of 
> those q-values were around 0.6.
> 
> Does anyone know how these q-values are calculated?
> 
> If the q-value is similar to p-value in interpretation, why these genes
> are 
> significant?
> 
> Should I take into account the q-values estimates for my analysis? What
> can 
> I say?
> 
> Thank in advance.
> Makis Motakis
> 
> ----------------------
> E Motakis, Mathematics
> E.Motakis at bristol.ac.uk
> 
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