[BioC] folate pathway is missing a key gene, MTHFR

Tomas Radivoyevitch radivot at hal.epbi.cwru.edu
Thu Jun 17 03:39:44 CEST 2004


Hi All,
FYI, I noticed that MTHFR, a key gene of the folate pathway, is not in the
pathway
00670 "One carbon pool by folate,"  though it certainly should be. For
example, this code

library(Biobase)
library(hgu133a)
library(KEGG)
IDs=get("00670", env = hgu133aPATH2PROBE);IDs
as.character(multiget(IDs, env = hgu133aSYMBOL))

fails to pick up these three probe sets for MTHFR:

206800_at MTHFR 1p36.3  5,10-methylenetetrahydrofolate reductase (NADPH)
217070_at MTHFR 1p36.3  5,10-methylenetetrahydrofolate reductase (NADPH)
217071_s_at MTHFR 1p36.3  5,10-methylenetetrahydrofolate reductase (NADPH)

Tom



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