[BioC] question abour background subtraction in RMA

[mai98ftu at studserv.uni-leipzig.de]

> What does the word adhoc means?

Citing http://www.m-w.com/home.htm:

  Main Entry: (1) ad hoc  
  Function: adverb
  Etymology: Latin, for this
  : for the particular end or case at hand without consideration of wider 
application  

  Main Entry: (2) ad hoc
  Function: adjective
  1 a : concerned with a particular end or purpose <an ad hoc investigating 
committee> 
  1 b : formed or used for specific or immediate problems or needs <ad hoc 
solutions>
  2 : fashioned from whatever is immediately available : IMPROVISED <large ad 
hoc parades and demonstrations -- Nat Hentoff> 


> Can someone explain me the way these parameters are estimated?

You can type the function name (without parentheses) to get the source code, 
simply type: bg.correct.rma, bg.adjust, and bg.parameters respectively.

Hope that helps?

Best regard,
Johannes



Zitiere "Antille,Nicolas,LAUSANNE,NRC-BAS" <nicolas.antille at rdls.nestle.com>:

> Hello!
> 
> I'm currently studying in details the Robust Multichip Average procedure
> for
> normalizing microarrays data. I am particulary intersted in the
> background
> subtraction. In the description of the affy package, it is said the the
> function bg.parameters provides adhoc estimates of the parameters of
> the
> normal and exponential distributions. What does the word adhoc means?
> Can someone explain me the way these parameters are estimated?
> 
> Thanks in advance!
> 
> Regards
> 
> Nicolas
> 
>  
> Nicolas Antille 
> Statistician 
> Nestlé Research Center 
> PO Box 44, CH-1000 Lausanne 26 
> Phone: + 41 21 785 9433 
> <mailto:nicolas.antille at rdls.nestle.com>
> 
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