[BioC] SAM for R
Stephen Eglen
stephen at inf.ed.ac.uk
Wed Jun 4 11:41:35 MEST 2003
> I have been using the affy package to summarize and filter .cel files into
> expression sets, then exporting these sets into SAM (Significance Analysis
> of Microarrays) to select differentially expressed genes.
> This is getting cumbersome; it would be more straightforward to do
> everything in R.
> Does anyone have functions for SAM in R, or can I use any of the existing
> bioconductor packages to select differentially expressed genes in a way
> similar to SAM?
hi Thomas, and others,
See the announcement below by Holger Schwender -- the R code works
fine.
Stephen
----------------------------------------------------------------------
because of the large number of requests I uploaded my functions
that can perform the SAM analysis and the Empirical Bayes Analysis
described in the JASA-Paper of Efron to the internet. You can
download the S-Plus functions from
http://de.geocities.com/holgerschw/GENE-SIG.ZIP
A short description you will find under
http://de.geocities.com/holgerschw/gene-sig.pdf
An older version of the R functions is available at
http://de.geocities.com/holgerschw/r.zip
These R functions cannot handle a very large number of permutations
(let's say B larger than 500 or 1000). There is a newer version of
these functions that can handle this number of permutations. I will
post these functions as soon as I am back home (Sunday or Monday).
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