Figure 5 in the recent Nucleic Acids Research 2003, Vol. 31, No. 4 e15 (http://nar.oupjournals.org/cgi/content/full/31/4/e15/GNG015F5) shows an interesting asymmetry in the distribution of fold changes for non-spiked in genes. Can anyone comment on the reason for this? Here, dChip has the least amount of bias. Thanks, Chris