Right now, AlignedRead only contains the position for a mapped read and leaves off any indel information. GappedAlignments has this. Would it be possible to combine GappedAlignments and a QualityScaledXStringSet (i.e., from a ShortRead object) to get a QualityAlignedXStringSet? It would be nice to merge the sequence-based alignment infrastructure in Biostrings with the range-based alignment representation in GenomicRanges. Thoughts? Michael [[alternative HTML version deleted]]