[Bioc-devel] core dump in MotifDb build

Hervé Pagès hp@ge@ @end|ng |rom |redhutch@org
Fri Mar 27 03:19:15 CET 2020


Hi Paul,

I can reproduce this on my laptop. See full output below (it's big!). 
Make sure to use a recent version of R devel (I updated mine 3 days 
ago). The error seems to occur in MotIV's C/C++ code (in 
/home/hpages/R/R-4.0.r78037/library/MotIV/libs/MotIV.so on my machine).

2 unrelated things:
- Please add MotIV and seqLogo to your Suggests field (they're used in 
the vignette and/or the unit tests).
- Make sure to remove vignettes/MotifDb.tex

Best,
H.

----------------------------------------------------------------------

hpages using spectre:~/MotifDb/vignettes$ R-4.0 CMD Stangle MotifDb.Rnw
Output file:  MotifDb.R

hpages using spectre:~/MotifDb/vignettes$ R-4.0

R Under development (unstable) (2020-03-23 r78037) -- "Unsuffered 
Consequences"
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Type 'demo()' for some demos, 'help()' for on-line help, or
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 > source("MotifDb.R", echo=TRUE)

 > ### R code from vignette source 
'/home/hpages/git.bioconductor.org/software/MotifDb/vignettes/MotifDb.Rnw'
 >
 > #################################### .... [TRUNCATED]
Loading required package: BiocGenerics
Loading required package: parallel

Attaching package: ‘BiocGenerics’

The following objects are masked from ‘package:parallel’:

     clusterApply, clusterApplyLB, clusterCall, clusterEvalQ,
     clusterExport, clusterMap, parApply, parCapply, parLapply,
     parLapplyLB, parRapply, parSapply, parSapplyLB

The following objects are masked from ‘package:stats’:

     IQR, mad, sd, var, xtabs

The following objects are masked from ‘package:base’:

     anyDuplicated, append, as.data.frame, basename, cbind, colnames,
     dirname, do.call, duplicated, eval, evalq, Filter, Find, get, grep,
     grepl, intersect, is.unsorted, lapply, Map, mapply, match, mget,
     order, paste, pmax, pmax.int, pmin, pmin.int, Position, rank,
     rbind, Reduce, rownames, sapply, setdiff, sort, table, tapply,
     union, unique, unsplit, which, which.max, which.min

Loading required package: S4Vectors
Loading required package: stats4

Attaching package: ‘S4Vectors’

The following object is masked from ‘package:base’:

     expand.grid

Loading required package: IRanges
Loading required package: GenomicRanges
Loading required package: GenomeInfoDb
Loading required package: Biostrings
Loading required package: XVector

Attaching package: ‘Biostrings’

The following object is masked from ‘package:base’:

     strsplit


Registered S3 method overwritten by 'treeio':
   method     from
   root.phylo ape
See system.file("LICENSE", package="MotifDb") for use restrictions.

 > library (MotIV)

Attaching package: ‘MotIV’

The following object is masked from ‘package:stats’:

     filter


 > library (seqLogo)
Loading required package: grid

Attaching package: ‘seqLogo’

The following object is masked from ‘package:MotIV’:

     makePWM


 > ###################################################
 > ### code chunk number 2: MotifDb.Rnw:71-90
 > ################################################# .... [TRUNCATED]

 > ###################################################
 > ### code chunk number 3: sources
 > ###################################################
 > lengt .... [TRUNCATED]
[1] 10701

 > sort (table (values (MotifDb)$dataSource), decreasing=TRUE)

              jaspar2018              jaspar2016             HOCOMOCOv10
                    1564                    1209                    1066
              cisbp_1.02               jolma2013            SwissRegulon
                     874                     843                     684
                 stamlab         FlyFactorSurvey             JASPAR_2014
                     683                     614                     592
             JASPAR_CORE                    hPDI                UniPROBE
                     459                     437                     380
                   HOMER HOCOMOCOv11-secondary-D                  ScerTF
                     332                     290                     196
      HOCOMOCOv11-core-A      HOCOMOCOv11-core-C      HOCOMOCOv11-core-B
                     181                     135                      84
HOCOMOCOv11-secondary-A HOCOMOCOv11-secondary-B HOCOMOCOv11-secondary-C
                      46                      19                      13

 > ###################################################
 > ### code chunk number 4: organisms
 > ###################################################
 > sor .... [TRUNCATED]

 
Hsapiens
 
  5384
 
Mmusculus
 
  1411
 
Dmelanogaster
 
  1287
 
Scerevisiae
 
  1051
 
Athaliana
 
   803
 
Celegans
 
    90
 
    NA
 
    40
 
Rnorvegicus
 
    35
 
Pfalciparum
 
    28
 
Zmays
 
    27
 
Vertebrata
 
    18
 
Ncrassa
 
    15
 
Psativum
 
    13
 
Amajus
 
    12
 
Ddiscoideum
 
     9
 
Anidulans
 
     8
 
Ggallus
 
     8
 
Ppatens
 
     7
 
Xlaevis
 
     7
 
Mmusculus;Rnorvegicus;Hsapiens
 
     6
 
Osativa
 
     5
 
Hroretzi
 
     4
 
Hvulgare
 
     4
 
Ocuniculus
 
     4
 
Phybrida
 
     4
 
Rrattus
 
     4
 
Taestivam
 
     4
 
Drerio
 
     3
 
Gallus
 
     3
 
Mmusculus;Hsapiens
 
     3
 
Bdistachyon
 
     2
 
Cparvum
 
     2
 
Csativa
 
     2
 
Mmusculus;Rnorvegicus
 
     2
Mmusculus;Rnorvegicus;Xlaevis;Stropicalis;Ggallus;Hsapiens;Btaurus;Ocuniculus 

 
     2
 
  Nsp.
 
     2
 
Nsylvestris
 
     2
 
Otauri
 
     2
 
Acarolinensis
 
     1
 
Apisum
 
     1
 
Aterreus
 
     1
 
Gaculeatus
 
     1
 
Hcapsulatum
 
     1
 
Mdomestica
 
     1
 
Mgallopavo
 
     1
 
Mmurinus
 
     1
 
Mmusculus;Rnorvegicus;Hsapiens;Ocuniculus
 
     1
 
Mmusculus;Rnorvegicus;Omykiss;Ggallus;Hsapiens
 
     1
 
Mmusculus;Rrattus;Hsapiens;Ocuniculus
 
     1
 
Mtruncatula
 
     1
 
Ngruberi
 
     1
 
Nhaematococca
 
     1
 
Nvectensis
 
     1
 
Pcapensis
 
     1
 
Ppygmaeus
 
     1
 
Ptetraurelia
 
     1
 
Rnorvegicus;Hsapiens
 
     1
 
Tthermophila
 
     1
 
Vvinifera
 
     1
 
Xtropicalis
 
     1

 > ###################################################
 > ### code chunk number 5: metadata
 > ###################################################
 > coln .... [TRUNCATED]
  [1] "providerName"    "providerId"      "dataSource"      "geneSymbol" 

  [5] "geneId"          "geneIdType"      "proteinId" 
"proteinIdType"
  [9] "organism"        "sequenceCount"   "bindingSequence" 
"bindingDomain"
[13] "tfFamily"        "experimentType"  "pubmedID"

 > ###################################################
 > ### code chunk number 6: queryHuman
 > ###################################################
 > qu .... [TRUNCATED]
MotifDb object of length 5399
| Created from downloaded public sources: 2013-Aug-30
| 5399 position frequency matrices from 18 sources:
|         cisbp_1.02:  313
|        HOCOMOCOv10:  640
| HOCOMOCOv11-core-A:  181
| HOCOMOCOv11-core-B:   84
| HOCOMOCOv11-core-C:  135
| HOCOMOCOv11-secondary-A:   46
| HOCOMOCOv11-secondary-B:   19
| HOCOMOCOv11-secondary-C:   13
| HOCOMOCOv11-secondary-D:  290
|               hPDI:  437
|        JASPAR_2014:  117
|        JASPAR_CORE:   66
|         jaspar2016:  442
|         jaspar2018:  537
|          jolma2013:  710
|            stamlab:  683
|       SwissRegulon:  684
|           UniPROBE:    2
| 8 organism/s
|           Hsapiens: 5384
| Mmusculus;Rnorvegicus;Hsapiens:    6
| Mmusculus;Hsapiens:    3
| 
Mmusculus;Rnorvegicus;Xlaevis;Stropicalis;Ggallus;Hsapiens;Btaurus;Ocuniculus: 
    2
| Mmusculus;Rnorvegicus;Hsapiens;Ocuniculus:    1
| Mmusculus;Rnorvegicus;Omykiss;Ggallus;Hsapiens:    1
|              other:    2
Hsapiens-cisbp_1.02-M1838_1.02
Hsapiens-cisbp_1.02-M1857_1.02
Hsapiens-cisbp_1.02-M1875_1.02
Hsapiens-cisbp_1.02-M1880_1.02
Hsapiens-cisbp_1.02-M1889_1.02
...
Hsapiens-SwissRegulon-ZNF784.SwissRegulon
Hsapiens-SwissRegulon-ZNF8.SwissRegulon
Hsapiens-SwissRegulon-ZSCAN4.SwissRegulon
Hsapiens-UniPROBE-Sox4.UP00401
Hsapiens-UniPROBE-Oct_1.UP00399

 > ###################################################
 > ### code chunk number 7: querySox
 > ###################################################
 > quer .... [TRUNCATED]
MotifDb object of length 196
| Created from downloaded public sources: 2013-Aug-30
| 196 position frequency matrices from 17 sources:
|    FlyFactorSurvey:    2
|        HOCOMOCOv10:   25
| HOCOMOCOv11-core-A:    1
| HOCOMOCOv11-core-B:    5
| HOCOMOCOv11-core-C:    2
| HOCOMOCOv11-secondary-A:    2
| HOCOMOCOv11-secondary-B:    1
| HOCOMOCOv11-secondary-D:    9
|              HOMER:    9
|               hPDI:    2
|        JASPAR_2014:    8
|        JASPAR_CORE:    5
|         jaspar2016:   16
|         jaspar2018:   19
|          jolma2013:   56
|       SwissRegulon:   19
|           UniPROBE:   15
| 7 organism/s
|           Hsapiens:  115
|          Mmusculus:   67
|      Dmelanogaster:    2
| Mmusculus;Rnorvegicus;Hsapiens:    1
|        Rnorvegicus:    1
|         Vertebrata:    1
|              other:    9
Dmelanogaster-FlyFactorSurvey-Sox14_SANGER_10_FBgn0005612
Dmelanogaster-FlyFactorSurvey-Sox15_SANGER_5_FBgn0005613
Hsapiens-HOCOMOCOv10-SOX10_HUMAN.H10MO.D
Hsapiens-HOCOMOCOv10-SOX11_HUMAN.H10MO.D
Hsapiens-HOCOMOCOv10-SOX13_HUMAN.H10MO.D
...
Mmusculus-UniPROBE-Sox30.UP00023
Mmusculus-UniPROBE-Sox4.UP00062
Mmusculus-UniPROBE-Sox5.UP00091
Mmusculus-UniPROBE-Sox7.UP00034
Mmusculus-UniPROBE-Sox8.UP00051

 > ###################################################
 > ### code chunk number 8: queryYeastHomeo
 > ################################################### .... [TRUNCATED]
MotifDb object of length 32
| Created from downloaded public sources: 2013-Aug-30
| 32 position frequency matrices from 5 sources:
|        JASPAR_2014:   10
|        JASPAR_CORE:   10
|         jaspar2016:    4
|         jaspar2018:    4
|           UniPROBE:    4
| 1 organism/s
|        Scerevisiae:   32
Scerevisiae-JASPAR_CORE-CUP9-MA0288.1
Scerevisiae-JASPAR_CORE-HMRA2-MA0318.1
Scerevisiae-JASPAR_CORE-MATA1-MA0327.1
Scerevisiae-JASPAR_CORE-MATALPHA2-MA0328.1
Scerevisiae-JASPAR_CORE-PHO2-MA0356.1
...
Scerevisiae-jaspar2018-TOS8-MA0408.1
Scerevisiae-UniPROBE-Cup9.UP00308
Scerevisiae-UniPROBE-Matalpha2.UP00307
Scerevisiae-UniPROBE-Pho2.UP00268
Scerevisiae-UniPROBE-Yox1.UP00274

 > ###################################################
 > ### code chunk number 9: homeoVariety
 > ###################################################
 >  .... [TRUNCATED]
  [1] "Homeobox"                          "Hox9_act;Homeobox" 

  [3] "LIM;Homeobox"                      "PAX;Homeobox" 

  [5] "OAR;Homeobox"                      "Pou;Homeobox" 

  [7] "Distant similarity to homeodomain" "Homeo" 

  [9] "Homeo, PAX"                        "Homeo, POU" 


 > unique (grep ('homeo', values(MotifDb)$tfFamily, ignore.case=T, v=T))
  [1] "HOX-related factors{3.1.1}: CDX (Caudal type homeobox){3.1.1.9}" 

  [2] "HOX-related factors{3.1.1}: GBX (Gastrulation brain 
homeobox){3.1.1.11}"
  [3] "TALE-type homeo domain factors{3.1.4}: IRX (Iroquois){3.1.4.1}" 

  [4] "TALE-type homeo domain factors{3.1.4}: MEIS{3.1.4.2}" 

  [5] "Paired domain only{3.2.2}: PAX-1/9 (no homeo remnant){3.2.2.1}" 

  [6] "Paired domain only{3.2.2}: PAX-2-like factors (partial 
homeobox){3.2.2.2}"
  [7] "Paired plus homeo domain{3.2.1}: PAX-3/7{3.2.1.1}" 

  [8] "Paired plus homeo domain{3.2.1}: PAX-4/6{3.2.1.2}" 

  [9] "TALE-type homeo domain factors{3.1.4}: PBX{3.1.4.4}" 

[10] "TALE-type homeo domain factors{3.1.4}: PKNOX{3.1.4.5}" 

[11] "TALE-type homeo domain factors{3.1.4}: TGIF{3.1.4.6}" 

[12] "Homeo" 

[13] "Homeo::Nuclear Factor I-CCAAT-binding" 

[14] "Homeodomain" 

[15] "Paired plus homeo domain" 

[16] "TALE-type homeo domain factors" 

[17] "homeodomain" 


 > ###################################################
 > ### code chunk number 10: grepHuman
 > ###################################################
 > md .... [TRUNCATED]

 > mdb.sox <- MotifDb [grep ('sox', values (MotifDb)$geneSymbol, 
ignore.case=TRUE)]

 > yeast.indices = grepl ('scere', values (MotifDb)$organism, 
ignore.case=TRUE)

 > homeo.indices.domain = grepl ('homeo', values 
(MotifDb)$bindingDomain, ignore.case=TRUE)

 > homeo.indices.family = grepl ('homeo', values (MotifDb)$tfFamily, 
ignore.case=TRUE)

 > yeast.homeo.indices = yeast.indices & (homeo.indices.domain | 
homeo.indices.family)

 > yeast.homeoDb = MotifDb [yeast.homeo.indices]

 > ###################################################
 > ### code chunk number 11: withHomeo
 > ###################################################
 > ye .... [TRUNCATED]

 > ###################################################
 > ### code chunk number 12: subsetHuman
 > ###################################################
 >  .... [TRUNCATED]
MotifDb object of length 5384
| Created from downloaded public sources: 2013-Aug-30
| 5384 position frequency matrices from 18 sources:
|         cisbp_1.02:  313
|        HOCOMOCOv10:  640
| HOCOMOCOv11-core-A:  181
| HOCOMOCOv11-core-B:   84
| HOCOMOCOv11-core-C:  135
| HOCOMOCOv11-secondary-A:   46
| HOCOMOCOv11-secondary-B:   19
| HOCOMOCOv11-secondary-C:   13
| HOCOMOCOv11-secondary-D:  290
|               hPDI:  437
|        JASPAR_2014:  117
|        JASPAR_CORE:   66
|         jaspar2016:  442
|         jaspar2018:  522
|          jolma2013:  710
|            stamlab:  683
|       SwissRegulon:  684
|           UniPROBE:    2
| 1 organism/s
|           Hsapiens: 5384
Hsapiens-cisbp_1.02-M1838_1.02
Hsapiens-cisbp_1.02-M1857_1.02
Hsapiens-cisbp_1.02-M1875_1.02
Hsapiens-cisbp_1.02-M1880_1.02
Hsapiens-cisbp_1.02-M1889_1.02
...
Hsapiens-SwissRegulon-ZNF784.SwissRegulon
Hsapiens-SwissRegulon-ZNF8.SwissRegulon
Hsapiens-SwissRegulon-ZSCAN4.SwissRegulon
Hsapiens-UniPROBE-Sox4.UP00401
Hsapiens-UniPROBE-Oct_1.UP00399

 > ###################################################
 > ### code chunk number 13: subsetSox
 > ###################################################
 > if .... [TRUNCATED]
MotifDb object of length 10
| Created from downloaded public sources: 2013-Aug-30
| 10 position frequency matrices from 8 sources:
|        HOCOMOCOv10:    2
| HOCOMOCOv11-core-B:    1
|              HOMER:    1
|         jaspar2016:    1
|         jaspar2018:    1
|          jolma2013:    1
|       SwissRegulon:    1
|           UniPROBE:    2
| 3 organism/s
|           Hsapiens:    7
|          Mmusculus:    2
|              other:    1
Hsapiens-HOCOMOCOv10-SOX4_HUMAN.H10MO.C
Mmusculus-HOCOMOCOv10-SOX4_MOUSE.H10MO.C
Hsapiens-HOCOMOCOv11-core-B-SOX4_HUMAN.H11MO.0.B
NA-HOMER-Sox4(HMG)/proB-Sox4-ChIP-Seq(GSE50066)/Homer
Hsapiens-jaspar2016-SOX4-MA0867.1
Hsapiens-jaspar2018-SOX4-MA0867.1
Hsapiens-jolma2013-SOX4
Hsapiens-SwissRegulon-SOX4.SwissRegulon
Hsapiens-UniPROBE-Sox4.UP00401
Mmusculus-UniPROBE-Sox4.UP00062

 > ###################################################
 > ### code chunk number 14: subsetYeastHomeo
 > ################################################# .... [TRUNCATED]
MotifDb object of length 4
| Created from downloaded public sources: 2013-Aug-30
| 4 position frequency matrices from 1 source:
|           UniPROBE:    4
| 1 organism/s
|        Scerevisiae:    4
Scerevisiae-UniPROBE-Cup9.UP00308
Scerevisiae-UniPROBE-Matalpha2.UP00307
Scerevisiae-UniPROBE-Pho2.UP00268
Scerevisiae-UniPROBE-Yox1.UP00274

 > ###################################################
 > ### code chunk number 15: findEgr1
 > ###################################################
 >   # .... [TRUNCATED]
$`Hsapiens-HOCOMOCOv10-EGR1_HUMAN.H10MO.A`
       1     2     3     4     5     6     7     8     9    10    11 
12    13
A 0.190 0.208 0.212 0.270 0.222 0.116 0.168 0.042 0.034 0.160 0.008 
0.032 0.262
C 0.192 0.206 0.144 0.140 0.074 0.082 0.484 0.042 0.008 0.006 0.000 
0.038 0.452
G 0.438 0.446 0.452 0.468 0.380 0.756 0.050 0.808 0.452 0.804 0.976 
0.914 0.006
T 0.180 0.140 0.192 0.122 0.324 0.046 0.298 0.108 0.506 0.030 0.016 
0.016 0.280
      14    15    16    17    18
A 0.180 0.072 0.236 0.278 0.218
C 0.012 0.012 0.092 0.098 0.184
G 0.750 0.774 0.534 0.458 0.490
T 0.058 0.142 0.138 0.166 0.108

$`Hsapiens-HOCOMOCOv10-EGR1_HUMAN.H10MO.S`
           1          2          3           4           5          6
A 0.1515633 0.04398516 0.05988341 0.003709592 0.009538951 0.07578166
C 0.1886592 0.06041335 0.82829889 0.001059883 0.013248543 0.01907790
G 0.3184950 0.88288288 0.01854796 0.993640700 0.490726020 0.90196078
T 0.3412825 0.01271860 0.09326974 0.001589825 0.486486486 0.00317965
             7          8           9          10         11
A 0.025437202 0.01218866 0.089030207 0.021727610 0.09062003
C 0.065712772 0.01006889 0.748277689 0.007419184 0.06518283
G 0.900900901 0.97774245 0.007419184 0.955484897 0.60943296
T 0.007949126 0.00000000 0.155272920 0.015368309 0.23476418

$`Mmusculus-HOCOMOCOv10-EGR1_MOUSE.H10MO.A`
           1          2          3           4           5          6
A 0.1515633 0.04398516 0.05988341 0.003709592 0.009538951 0.07578166
C 0.1886592 0.06041335 0.82829889 0.001059883 0.013248543 0.01907790
G 0.3184950 0.88288288 0.01854796 0.993640700 0.490726020 0.90196078
T 0.3412825 0.01271860 0.09326974 0.001589825 0.486486486 0.00317965
             7          8           9          10         11
A 0.025437202 0.01218866 0.089030207 0.021727610 0.09062003
C 0.065712772 0.01006889 0.748277689 0.007419184 0.06518283
G 0.900900901 0.97774245 0.007419184 0.955484897 0.60943296
T 0.007949126 0.00000000 0.155272920 0.015368309 0.23476418

$`Hsapiens-HOCOMOCOv11-core-A-EGR1_HUMAN.H11MO.0.A`
       1     2     3     4     5     6     7     8     9    10    11 
12    13
A 0.232 0.320 0.278 0.236 0.112 0.236 0.056 0.032 0.092 0.016 0.024 
0.220 0.088
C 0.248 0.128 0.180 0.112 0.030 0.506 0.034 0.004 0.002 0.004 0.032 
0.476 0.010
G 0.410 0.318 0.460 0.354 0.808 0.046 0.870 0.410 0.892 0.958 0.930 
0.004 0.842
T 0.110 0.234 0.082 0.298 0.050 0.212 0.040 0.554 0.014 0.022 0.014 
0.300 0.060
      14    15    16    17
A 0.110 0.338 0.312 0.264
C 0.022 0.128 0.082 0.182
G 0.696 0.406 0.456 0.436
T 0.172 0.128 0.150 0.118

$`NA-HOMER-Egr1(Zf)/K562-Egr1-ChIP-Seq(GSE32465)/Homer`
       1     2     3     4     5     6     7     8     9    10
A 0.128 0.078 0.154 0.001 0.001 0.027 0.001 0.001 0.153 0.034
C 0.072 0.036 0.523 0.001 0.001 0.001 0.002 0.001 0.415 0.002
G 0.142 0.882 0.023 0.997 0.282 0.971 0.973 0.997 0.010 0.940
T 0.658 0.004 0.300 0.001 0.716 0.001 0.024 0.001 0.422 0.024

$`Mmusculus-JASPAR_CORE-Egr1-MA0162.1`
            1          2         3 4   5   6          7 8         9 10
A 0.20000000 0.13333333 0.0000000 0 0.0 0.2 0.06666667 0 0.1333333  0
C 0.26666667 0.06666667 0.8666667 0 0.0 0.0 0.00000000 0 0.6666667  0
G 0.06666667 0.80000000 0.0000000 1 0.2 0.8 0.93333333 1 0.0000000  1
T 0.46666667 0.00000000 0.1333333 0 0.8 0.0 0.00000000 0 0.2000000  0
           11
A 0.06666667
C 0.00000000
G 0.46666667
T 0.46666667

$`Hsapiens-JASPAR_2014-EGR1-MA0162.2`
            1         2          3          4          5         6 7 
      8
A 0.08958877 0.1228786 0.09464752 0.10892624 0.01901110 0.2375163 0 
0.00000000
C 0.46736292 0.5586651 0.49355418 0.85109334 0.94435379 0.0000000 1 
0.96703655
G 0.25155026 0.1108845 0.18358355 0.00000000 0.00000000 0.5580940 0 
0.00000000
T 0.19149804 0.2075718 0.22821475 0.03998042 0.03663512 0.2043897 0 
0.03296345
            9         10         11        12         13        14
A 0.00000000 0.29797650 0.00000000 0.1932115 0.00000000 0.2468995
C 0.82849217 0.68219648 0.97519582 0.0000000 0.80360640 0.4565111
G 0.04985313 0.00000000 0.00000000 0.5384302 0.11586162 0.1560868
T 0.12165470 0.01982702 0.02480418 0.2683584 0.08053198 0.1405026

$`Mmusculus-jaspar2016-Egr1-MA0162.1`
            1          2         3 4   5   6          7 8         9 10
A 0.20000000 0.13333333 0.0000000 0 0.0 0.2 0.06666667 0 0.1333333  0
C 0.26666667 0.06666667 0.8666667 0 0.0 0.0 0.00000000 0 0.6666667  0
G 0.06666667 0.80000000 0.0000000 1 0.2 0.8 0.93333333 1 0.0000000  1
T 0.46666667 0.00000000 0.1333333 0 0.8 0.0 0.00000000 0 0.2000000  0
           11
A 0.06666667
C 0.00000000
G 0.46666667
T 0.46666667

$`Hsapiens-jaspar2016-EGR1-MA0162.2`
            1         2          3          4          5         6 7 
      8
A 0.08958877 0.1228786 0.09464752 0.10892624 0.01901110 0.2375163 0 
0.00000000
C 0.46736292 0.5586651 0.49355418 0.85109334 0.94435379 0.0000000 1 
0.96703655
G 0.25155026 0.1108845 0.18358355 0.00000000 0.00000000 0.5580940 0 
0.00000000
T 0.19149804 0.2075718 0.22821475 0.03998042 0.03663512 0.2043897 0 
0.03296345
            9         10         11        12         13        14
A 0.00000000 0.29797650 0.00000000 0.1932115 0.00000000 0.2468995
C 0.82849217 0.68219648 0.97519582 0.0000000 0.80360640 0.4565111
G 0.04985313 0.00000000 0.00000000 0.5384302 0.11586162 0.1560868
T 0.12165470 0.01982702 0.02480418 0.2683584 0.08053198 0.1405026

$`Mmusculus-jaspar2018-Egr1-MA0162.1`
            1          2         3 4   5   6          7 8         9 10
A 0.20000000 0.13333333 0.0000000 0 0.0 0.2 0.06666667 0 0.1333333  0
C 0.26666667 0.06666667 0.8666667 0 0.0 0.0 0.00000000 0 0.6666667  0
G 0.06666667 0.80000000 0.0000000 1 0.2 0.8 0.93333333 1 0.0000000  1
T 0.46666667 0.00000000 0.1333333 0 0.8 0.0 0.00000000 0 0.2000000  0
           11
A 0.06666667
C 0.00000000
G 0.46666667
T 0.46666667

$`Hsapiens-jaspar2018-EGR1-MA0162.2`
            1         2          3          4          5         6 7 
      8
A 0.08958877 0.1228786 0.09464752 0.10892624 0.01901110 0.2375163 0 
0.00000000
C 0.46736292 0.5586651 0.49355418 0.85109334 0.94435379 0.0000000 1 
0.96703655
G 0.25155026 0.1108845 0.18358355 0.00000000 0.00000000 0.5580940 0 
0.00000000
T 0.19149804 0.2075718 0.22821475 0.03998042 0.03663512 0.2043897 0 
0.03296345
            9         10         11        12         13        14
A 0.00000000 0.29797650 0.00000000 0.1932115 0.00000000 0.2468995
C 0.82849217 0.68219648 0.97519582 0.0000000 0.80360640 0.4565111
G 0.04985313 0.00000000 0.00000000 0.5384302 0.11586162 0.1560868
T 0.12165470 0.01982702 0.02480418 0.2683584 0.08053198 0.1405026

$`Hsapiens-jaspar2018-EGR1-MA0162.3`
           1           2           3          4 5           6         7
A 0.2722977 0.737507906 0.006723716 0.01834431 0 0.000000000 0.0000000
C 0.2309510 0.249209361 0.987775061 0.00000000 1 0.992159228 0.9797136
G 0.1139988 0.001897533 0.001833741 0.98165569 0 0.000000000 0.0000000
T 0.3827525 0.011385199 0.003667482 0.00000000 0 0.007840772 0.0202864
             8            9           10         11         12         13
A 0.795439739 0.0000000000 0.0000000000 0.00000000 0.86166008 0.29390244
C 0.200000000 0.9993943065 0.0000000000 0.99220156 0.01317523 0.27926829
G 0.004560261 0.0000000000 0.9990732159 0.00000000 0.10540184 0.06341463
T 0.000000000 0.0006056935 0.0009267841 0.00779844 0.01976285 0.36341463
          14
A 0.3035714
C 0.1255952
G 0.1077381
T 0.4630952

$`Hsapiens-jolma2013-EGR1`
           1          2           3           4           5           6
A 0.2494781 0.51390568 0.003223727 0.105202754 0.000000000 0.002604167
C 0.2411273 0.39540508 0.969696970 0.005355777 0.980025773 0.992838542
G 0.1539666 0.03627570 0.007736944 0.854246366 0.007731959 0.000000000
T 0.3554280 0.05441354 0.019342360 0.035195103 0.012242268 0.004557292
             7           8           9         10       11         12 
     13
A 0.000000000 0.652638191 0.003253090 0.01906158 0.010000 0.68089431 
0.2790573
C 0.928214732 0.343592965 0.995445673 0.01136364 0.938125 0.06910569 
0.2485270
G 0.009363296 0.000000000 0.000000000 0.93181818 0.011875 0.14227642 
0.1253348
T 0.062421973 0.003768844 0.001301236 0.03775660 0.040000 0.10772358 
0.3470809
          14
A 0.2673936
C 0.1905504
G 0.1396677
T 0.4023884

$`Hsapiens-jolma2013-EGR1-2`
           1           2           3          4 5           6         7
A 0.2722977 0.737507906 0.006723716 0.01834431 0 0.000000000 0.0000000
C 0.2309510 0.249209361 0.987775061 0.00000000 1 0.992159228 0.9797136
G 0.1139988 0.001897533 0.001833741 0.98165569 0 0.000000000 0.0000000
T 0.3827525 0.011385199 0.003667482 0.00000000 0 0.007840772 0.0202864
             8            9           10         11         12         13
A 0.795439739 0.0000000000 0.0000000000 0.00000000 0.86166008 0.29390244
C 0.200000000 0.9993943065 0.0000000000 0.99220156 0.01317523 0.27926829
G 0.004560261 0.0000000000 0.9990732159 0.00000000 0.10540184 0.06341463
T 0.000000000 0.0006056935 0.0009267841 0.00779844 0.01976285 0.36341463
          14
A 0.3035714
C 0.1255952
G 0.1077381
T 0.4630952

$`Mmusculus-jolma2013-Egr1`
           1          2           3            4           5            6
A 0.3231418 0.32278481 0.618181818 0.0000000000 0.075444498 0.0000000000
C 0.3241961 0.30907173 0.366753247 0.9968454259 0.004324844 0.9994728519
G 0.1133368 0.03691983 0.003636364 0.0005257624 0.911100432 0.0005271481
T 0.2393253 0.33122363 0.011428571 0.0026288118 0.009130226 0.0000000000
             7 8           9          10         11          12         13
A 0.001578117 0 0.517114271 0.003149606 0.00422833 0.001579779 0.89181562
C 0.997369805 1 0.481305951 0.995275591 0.16732105 0.998420221 0.05738476
G 0.001052078 0 0.001579779 0.000000000 0.25581395 0.000000000 0.03621825
T 0.000000000 0 0.000000000 0.001574803 0.57263667 0.000000000 0.01458137
           14         15         16
A 0.44251055 0.31170886 0.26213080
C 0.32278481 0.19778481 0.31012658
G 0.04957806 0.04272152 0.09651899
T 0.18512658 0.44778481 0.33122363

$`Hsapiens-SwissRegulon-EGR1.SwissRegulon`
            1          2         3 4   5   6          7 8         9 10
A 0.20000000 0.13333333 0.0000000 0 0.0 0.2 0.06666667 0 0.1333333  0
C 0.26666667 0.06666667 0.8666667 0 0.0 0.0 0.00000000 0 0.6666667  0
G 0.06666667 0.80000000 0.0000000 1 0.2 0.8 0.93333333 1 0.0000000  1
T 0.46666667 0.00000000 0.1333333 0 0.8 0.0 0.00000000 0 0.2000000  0
           11
A 0.06666667
C 0.00000000
G 0.46666667
T 0.46666667

$`Mmusculus-UniPROBE-Egr1.UP00007`
           1          2          3          4           5           6
A 0.2115466 0.14198757 0.03260499 0.11512588 0.003516173 0.004715059
C 0.2827083 0.72243721 0.87717185 0.07060553 0.990021152 0.982482238
G 0.2034722 0.05485440 0.01243161 0.78128969 0.002264928 0.009896878
T 0.3022730 0.08072082 0.07779155 0.03297890 0.004197748 0.002905824
             7           8           9         10         11         12
A 0.001626612 0.262351637 0.005889514 0.02289301 0.02303758 0.56763334
C 0.975937323 0.731731673 0.985755764 0.09046006 0.85994854 0.05739392
G 0.001661635 0.002729558 0.002081402 0.64932246 0.03791264 0.16679165
T 0.020774430 0.003187133 0.006273319 0.23732447 0.07910124 0.20818108
          13        14
A 0.1765973 0.1830489
C 0.3312648 0.1837744
G 0.1253083 0.2267928
T 0.3668295 0.4063840


 >   # grep returns indices which allow for more flexibility
 > indices = grep ('egr1', values (MotifDb)$geneSymbol, ignore.case=TRUE)

 > length (indices)
[1] 17

 > ###################################################
 > ### code chunk number 16: MotifDbViews
 > ###################################################
 > .... [TRUNCATED]
MotifDb object of length 17
| Created from downloaded public sources: 2013-Aug-30
| 17 position frequency matrices from 10 sources:
|        HOCOMOCOv10:    3
| HOCOMOCOv11-core-A:    1
|              HOMER:    1
|        JASPAR_2014:    1
|        JASPAR_CORE:    1
|         jaspar2016:    2
|         jaspar2018:    3
|          jolma2013:    3
|       SwissRegulon:    1
|           UniPROBE:    1
| 3 organism/s
|           Hsapiens:   10
|          Mmusculus:    6
|              other:    1
Hsapiens-HOCOMOCOv10-EGR1_HUMAN.H10MO.A
Hsapiens-HOCOMOCOv10-EGR1_HUMAN.H10MO.S
Mmusculus-HOCOMOCOv10-EGR1_MOUSE.H10MO.A
Hsapiens-HOCOMOCOv11-core-A-EGR1_HUMAN.H11MO.0.A
NA-HOMER-Egr1(Zf)/K562-Egr1-ChIP-Seq(GSE32465)/Homer
...
Hsapiens-jolma2013-EGR1
Hsapiens-jolma2013-EGR1-2
Mmusculus-jolma2013-Egr1
Hsapiens-SwissRegulon-EGR1.SwissRegulon
Mmusculus-UniPROBE-Egr1.UP00007

 > ###################################################
 > ### code chunk number 17: as.list
 > ###################################################
 > as.l .... [TRUNCATED]
$`Hsapiens-HOCOMOCOv10-EGR1_HUMAN.H10MO.A`
       1     2     3     4     5     6     7     8     9    10    11 
12    13
A 0.190 0.208 0.212 0.270 0.222 0.116 0.168 0.042 0.034 0.160 0.008 
0.032 0.262
C 0.192 0.206 0.144 0.140 0.074 0.082 0.484 0.042 0.008 0.006 0.000 
0.038 0.452
G 0.438 0.446 0.452 0.468 0.380 0.756 0.050 0.808 0.452 0.804 0.976 
0.914 0.006
T 0.180 0.140 0.192 0.122 0.324 0.046 0.298 0.108 0.506 0.030 0.016 
0.016 0.280
      14    15    16    17    18
A 0.180 0.072 0.236 0.278 0.218
C 0.012 0.012 0.092 0.098 0.184
G 0.750 0.774 0.534 0.458 0.490
T 0.058 0.142 0.138 0.166 0.108

$`Hsapiens-HOCOMOCOv10-EGR1_HUMAN.H10MO.S`
           1          2          3           4           5          6
A 0.1515633 0.04398516 0.05988341 0.003709592 0.009538951 0.07578166
C 0.1886592 0.06041335 0.82829889 0.001059883 0.013248543 0.01907790
G 0.3184950 0.88288288 0.01854796 0.993640700 0.490726020 0.90196078
T 0.3412825 0.01271860 0.09326974 0.001589825 0.486486486 0.00317965
             7          8           9          10         11
A 0.025437202 0.01218866 0.089030207 0.021727610 0.09062003
C 0.065712772 0.01006889 0.748277689 0.007419184 0.06518283
G 0.900900901 0.97774245 0.007419184 0.955484897 0.60943296
T 0.007949126 0.00000000 0.155272920 0.015368309 0.23476418

$`Mmusculus-HOCOMOCOv10-EGR1_MOUSE.H10MO.A`
           1          2          3           4           5          6
A 0.1515633 0.04398516 0.05988341 0.003709592 0.009538951 0.07578166
C 0.1886592 0.06041335 0.82829889 0.001059883 0.013248543 0.01907790
G 0.3184950 0.88288288 0.01854796 0.993640700 0.490726020 0.90196078
T 0.3412825 0.01271860 0.09326974 0.001589825 0.486486486 0.00317965
             7          8           9          10         11
A 0.025437202 0.01218866 0.089030207 0.021727610 0.09062003
C 0.065712772 0.01006889 0.748277689 0.007419184 0.06518283
G 0.900900901 0.97774245 0.007419184 0.955484897 0.60943296
T 0.007949126 0.00000000 0.155272920 0.015368309 0.23476418

$`Hsapiens-HOCOMOCOv11-core-A-EGR1_HUMAN.H11MO.0.A`
       1     2     3     4     5     6     7     8     9    10    11 
12    13
A 0.232 0.320 0.278 0.236 0.112 0.236 0.056 0.032 0.092 0.016 0.024 
0.220 0.088
C 0.248 0.128 0.180 0.112 0.030 0.506 0.034 0.004 0.002 0.004 0.032 
0.476 0.010
G 0.410 0.318 0.460 0.354 0.808 0.046 0.870 0.410 0.892 0.958 0.930 
0.004 0.842
T 0.110 0.234 0.082 0.298 0.050 0.212 0.040 0.554 0.014 0.022 0.014 
0.300 0.060
      14    15    16    17
A 0.110 0.338 0.312 0.264
C 0.022 0.128 0.082 0.182
G 0.696 0.406 0.456 0.436
T 0.172 0.128 0.150 0.118

$`NA-HOMER-Egr1(Zf)/K562-Egr1-ChIP-Seq(GSE32465)/Homer`
       1     2     3     4     5     6     7     8     9    10
A 0.128 0.078 0.154 0.001 0.001 0.027 0.001 0.001 0.153 0.034
C 0.072 0.036 0.523 0.001 0.001 0.001 0.002 0.001 0.415 0.002
G 0.142 0.882 0.023 0.997 0.282 0.971 0.973 0.997 0.010 0.940
T 0.658 0.004 0.300 0.001 0.716 0.001 0.024 0.001 0.422 0.024

$`Mmusculus-JASPAR_CORE-Egr1-MA0162.1`
            1          2         3 4   5   6          7 8         9 10
A 0.20000000 0.13333333 0.0000000 0 0.0 0.2 0.06666667 0 0.1333333  0
C 0.26666667 0.06666667 0.8666667 0 0.0 0.0 0.00000000 0 0.6666667  0
G 0.06666667 0.80000000 0.0000000 1 0.2 0.8 0.93333333 1 0.0000000  1
T 0.46666667 0.00000000 0.1333333 0 0.8 0.0 0.00000000 0 0.2000000  0
           11
A 0.06666667
C 0.00000000
G 0.46666667
T 0.46666667

$`Hsapiens-JASPAR_2014-EGR1-MA0162.2`
            1         2          3          4          5         6 7 
      8
A 0.08958877 0.1228786 0.09464752 0.10892624 0.01901110 0.2375163 0 
0.00000000
C 0.46736292 0.5586651 0.49355418 0.85109334 0.94435379 0.0000000 1 
0.96703655
G 0.25155026 0.1108845 0.18358355 0.00000000 0.00000000 0.5580940 0 
0.00000000
T 0.19149804 0.2075718 0.22821475 0.03998042 0.03663512 0.2043897 0 
0.03296345
            9         10         11        12         13        14
A 0.00000000 0.29797650 0.00000000 0.1932115 0.00000000 0.2468995
C 0.82849217 0.68219648 0.97519582 0.0000000 0.80360640 0.4565111
G 0.04985313 0.00000000 0.00000000 0.5384302 0.11586162 0.1560868
T 0.12165470 0.01982702 0.02480418 0.2683584 0.08053198 0.1405026

$`Mmusculus-jaspar2016-Egr1-MA0162.1`
            1          2         3 4   5   6          7 8         9 10
A 0.20000000 0.13333333 0.0000000 0 0.0 0.2 0.06666667 0 0.1333333  0
C 0.26666667 0.06666667 0.8666667 0 0.0 0.0 0.00000000 0 0.6666667  0
G 0.06666667 0.80000000 0.0000000 1 0.2 0.8 0.93333333 1 0.0000000  1
T 0.46666667 0.00000000 0.1333333 0 0.8 0.0 0.00000000 0 0.2000000  0
           11
A 0.06666667
C 0.00000000
G 0.46666667
T 0.46666667

$`Hsapiens-jaspar2016-EGR1-MA0162.2`
            1         2          3          4          5         6 7 
      8
A 0.08958877 0.1228786 0.09464752 0.10892624 0.01901110 0.2375163 0 
0.00000000
C 0.46736292 0.5586651 0.49355418 0.85109334 0.94435379 0.0000000 1 
0.96703655
G 0.25155026 0.1108845 0.18358355 0.00000000 0.00000000 0.5580940 0 
0.00000000
T 0.19149804 0.2075718 0.22821475 0.03998042 0.03663512 0.2043897 0 
0.03296345
            9         10         11        12         13        14
A 0.00000000 0.29797650 0.00000000 0.1932115 0.00000000 0.2468995
C 0.82849217 0.68219648 0.97519582 0.0000000 0.80360640 0.4565111
G 0.04985313 0.00000000 0.00000000 0.5384302 0.11586162 0.1560868
T 0.12165470 0.01982702 0.02480418 0.2683584 0.08053198 0.1405026

$`Mmusculus-jaspar2018-Egr1-MA0162.1`
            1          2         3 4   5   6          7 8         9 10
A 0.20000000 0.13333333 0.0000000 0 0.0 0.2 0.06666667 0 0.1333333  0
C 0.26666667 0.06666667 0.8666667 0 0.0 0.0 0.00000000 0 0.6666667  0
G 0.06666667 0.80000000 0.0000000 1 0.2 0.8 0.93333333 1 0.0000000  1
T 0.46666667 0.00000000 0.1333333 0 0.8 0.0 0.00000000 0 0.2000000  0
           11
A 0.06666667
C 0.00000000
G 0.46666667
T 0.46666667

$`Hsapiens-jaspar2018-EGR1-MA0162.2`
            1         2          3          4          5         6 7 
      8
A 0.08958877 0.1228786 0.09464752 0.10892624 0.01901110 0.2375163 0 
0.00000000
C 0.46736292 0.5586651 0.49355418 0.85109334 0.94435379 0.0000000 1 
0.96703655
G 0.25155026 0.1108845 0.18358355 0.00000000 0.00000000 0.5580940 0 
0.00000000
T 0.19149804 0.2075718 0.22821475 0.03998042 0.03663512 0.2043897 0 
0.03296345
            9         10         11        12         13        14
A 0.00000000 0.29797650 0.00000000 0.1932115 0.00000000 0.2468995
C 0.82849217 0.68219648 0.97519582 0.0000000 0.80360640 0.4565111
G 0.04985313 0.00000000 0.00000000 0.5384302 0.11586162 0.1560868
T 0.12165470 0.01982702 0.02480418 0.2683584 0.08053198 0.1405026

$`Hsapiens-jaspar2018-EGR1-MA0162.3`
           1           2           3          4 5           6         7
A 0.2722977 0.737507906 0.006723716 0.01834431 0 0.000000000 0.0000000
C 0.2309510 0.249209361 0.987775061 0.00000000 1 0.992159228 0.9797136
G 0.1139988 0.001897533 0.001833741 0.98165569 0 0.000000000 0.0000000
T 0.3827525 0.011385199 0.003667482 0.00000000 0 0.007840772 0.0202864
             8            9           10         11         12         13
A 0.795439739 0.0000000000 0.0000000000 0.00000000 0.86166008 0.29390244
C 0.200000000 0.9993943065 0.0000000000 0.99220156 0.01317523 0.27926829
G 0.004560261 0.0000000000 0.9990732159 0.00000000 0.10540184 0.06341463
T 0.000000000 0.0006056935 0.0009267841 0.00779844 0.01976285 0.36341463
          14
A 0.3035714
C 0.1255952
G 0.1077381
T 0.4630952

$`Hsapiens-jolma2013-EGR1`
           1          2           3           4           5           6
A 0.2494781 0.51390568 0.003223727 0.105202754 0.000000000 0.002604167
C 0.2411273 0.39540508 0.969696970 0.005355777 0.980025773 0.992838542
G 0.1539666 0.03627570 0.007736944 0.854246366 0.007731959 0.000000000
T 0.3554280 0.05441354 0.019342360 0.035195103 0.012242268 0.004557292
             7           8           9         10       11         12 
     13
A 0.000000000 0.652638191 0.003253090 0.01906158 0.010000 0.68089431 
0.2790573
C 0.928214732 0.343592965 0.995445673 0.01136364 0.938125 0.06910569 
0.2485270
G 0.009363296 0.000000000 0.000000000 0.93181818 0.011875 0.14227642 
0.1253348
T 0.062421973 0.003768844 0.001301236 0.03775660 0.040000 0.10772358 
0.3470809
          14
A 0.2673936
C 0.1905504
G 0.1396677
T 0.4023884

$`Hsapiens-jolma2013-EGR1-2`
           1           2           3          4 5           6         7
A 0.2722977 0.737507906 0.006723716 0.01834431 0 0.000000000 0.0000000
C 0.2309510 0.249209361 0.987775061 0.00000000 1 0.992159228 0.9797136
G 0.1139988 0.001897533 0.001833741 0.98165569 0 0.000000000 0.0000000
T 0.3827525 0.011385199 0.003667482 0.00000000 0 0.007840772 0.0202864
             8            9           10         11         12         13
A 0.795439739 0.0000000000 0.0000000000 0.00000000 0.86166008 0.29390244
C 0.200000000 0.9993943065 0.0000000000 0.99220156 0.01317523 0.27926829
G 0.004560261 0.0000000000 0.9990732159 0.00000000 0.10540184 0.06341463
T 0.000000000 0.0006056935 0.0009267841 0.00779844 0.01976285 0.36341463
          14
A 0.3035714
C 0.1255952
G 0.1077381
T 0.4630952

$`Mmusculus-jolma2013-Egr1`
           1          2           3            4           5            6
A 0.3231418 0.32278481 0.618181818 0.0000000000 0.075444498 0.0000000000
C 0.3241961 0.30907173 0.366753247 0.9968454259 0.004324844 0.9994728519
G 0.1133368 0.03691983 0.003636364 0.0005257624 0.911100432 0.0005271481
T 0.2393253 0.33122363 0.011428571 0.0026288118 0.009130226 0.0000000000
             7 8           9          10         11          12         13
A 0.001578117 0 0.517114271 0.003149606 0.00422833 0.001579779 0.89181562
C 0.997369805 1 0.481305951 0.995275591 0.16732105 0.998420221 0.05738476
G 0.001052078 0 0.001579779 0.000000000 0.25581395 0.000000000 0.03621825
T 0.000000000 0 0.000000000 0.001574803 0.57263667 0.000000000 0.01458137
           14         15         16
A 0.44251055 0.31170886 0.26213080
C 0.32278481 0.19778481 0.31012658
G 0.04957806 0.04272152 0.09651899
T 0.18512658 0.44778481 0.33122363

$`Hsapiens-SwissRegulon-EGR1.SwissRegulon`
            1          2         3 4   5   6          7 8         9 10
A 0.20000000 0.13333333 0.0000000 0 0.0 0.2 0.06666667 0 0.1333333  0
C 0.26666667 0.06666667 0.8666667 0 0.0 0.0 0.00000000 0 0.6666667  0
G 0.06666667 0.80000000 0.0000000 1 0.2 0.8 0.93333333 1 0.0000000  1
T 0.46666667 0.00000000 0.1333333 0 0.8 0.0 0.00000000 0 0.2000000  0
           11
A 0.06666667
C 0.00000000
G 0.46666667
T 0.46666667

$`Mmusculus-UniPROBE-Egr1.UP00007`
           1          2          3          4           5           6
A 0.2115466 0.14198757 0.03260499 0.11512588 0.003516173 0.004715059
C 0.2827083 0.72243721 0.87717185 0.07060553 0.990021152 0.982482238
G 0.2034722 0.05485440 0.01243161 0.78128969 0.002264928 0.009896878
T 0.3022730 0.08072082 0.07779155 0.03297890 0.004197748 0.002905824
             7           8           9         10         11         12
A 0.001626612 0.262351637 0.005889514 0.02289301 0.02303758 0.56763334
C 0.975937323 0.731731673 0.985755764 0.09046006 0.85994854 0.05739392
G 0.001661635 0.002729558 0.002081402 0.64932246 0.03791264 0.16679165
T 0.020774430 0.003187133 0.006273319 0.23732447 0.07910124 0.20818108
          13        14
A 0.1765973 0.1830489
C 0.3312648 0.1837744
G 0.1253083 0.2267928
T 0.3668295 0.4063840


 > ###################################################
 > ### code chunk number 18: as.metadata
 > ###################################################
 >  .... [TRUNCATED]
                 Hsapiens-HOCOMOCOv10-EGR1_HUMAN.H10MO.A
providerName    EGR1_HUMAN.H10MO.A
providerId      EGR1_HUMAN.H10MO.A
dataSource      HOCOMOCOv10
geneSymbol      EGR1
geneId          <NA>
geneIdType      <NA>
proteinId       P18146
proteinIdType   UNIPROT
organism        Hsapiens
sequenceCount   500
bindingSequence <NA>
bindingDomain   <NA>
tfFamily        <NA>
experimentType  low- and high-throughput methods
pubmedID        26586801
                 Hsapiens-HOCOMOCOv10-EGR1_HUMAN.H10MO.S
providerName    EGR1_HUMAN.H10MO.S
providerId      EGR1_HUMAN.H10MO.S
dataSource      HOCOMOCOv10
geneSymbol      EGR1
geneId          <NA>
geneIdType      <NA>
proteinId       P18146
proteinIdType   UNIPROT
organism        Hsapiens
sequenceCount   1887
bindingSequence <NA>
bindingDomain   <NA>
tfFamily        <NA>
experimentType  low- and high-throughput methods
pubmedID        26586801
                 Mmusculus-HOCOMOCOv10-EGR1_MOUSE.H10MO.A
providerName    EGR1_MOUSE.H10MO.A
providerId      EGR1_MOUSE.H10MO.A
dataSource      HOCOMOCOv10
geneSymbol      EGR1
geneId          <NA>
geneIdType      <NA>
proteinId       P08046
proteinIdType   UNIPROT
organism        Mmusculus
sequenceCount   1887
bindingSequence <NA>
bindingDomain   <NA>
tfFamily        <NA>
experimentType  low- and high-throughput methods
pubmedID        26586801
                 Hsapiens-HOCOMOCOv11-core-A-EGR1_HUMAN.H11MO.0.A 

providerName    EGR1_HUMAN.H11MO.0.A 

providerId      EGR1_HUMAN.H11MO.0.A 

dataSource      HOCOMOCOv11-core-A 

geneSymbol      EGR1 

geneId          1958 

geneIdType      ENTREZ 

proteinId       EGR1_HUMAN 

proteinIdType   UNIPROT 

organism        Hsapiens 

sequenceCount   500 

bindingSequence <NA> 

bindingDomain   <NA> 

tfFamily        Three-zinc finger Krüppel-related factors{2.3.1}: EGR 
factors{2.3.1.3}
experimentType  ChIP-Seq 

pubmedID        23175603 

                 NA-HOMER-Egr1(Zf)/K562-Egr1-ChIP-Seq(GSE32465)/Homer
providerName    Egr1(Zf)/K562-Egr1-ChIP-Seq(GSE32465)/Homer
providerId      Egr1(Zf)/K562-Egr1-ChIP-Seq(GSE32465)/Homer
dataSource      HOMER
geneSymbol      Egr1
geneId          <NA>
geneIdType      <NA>
proteinId       ?query=Egr1(Zf)_K562-Egr1-ChIP-Seq(GSE32465)
proteinIdType   UNIPROT
organism        <NA>
sequenceCount   1
bindingSequence <NA>
bindingDomain   <NA>
tfFamily        <NA>
experimentType  low- and high-throughput methods
pubmedID        26586801
                 Mmusculus-JASPAR_CORE-Egr1-MA0162.1
providerName    Egr1
providerId      MA0162.1
dataSource      JASPAR_CORE
geneSymbol      Egr1
geneId          13653
geneIdType      ENTREZ
proteinId       P08046
proteinIdType   UNIPROT
organism        Mmusculus
sequenceCount   15
bindingSequence <NA>
bindingDomain   Zinc-coordinating
tfFamily        BetaBetaAlpha-zinc finger
experimentType  bacterial 1-hybrid
pubmedID        16041365
                 Hsapiens-JASPAR_2014-EGR1-MA0162.2
providerName    EGR1
providerId      MA0162.2
dataSource      JASPAR_2014
geneSymbol      EGR1
geneId          1958
geneIdType      ENTREZ
proteinId       P18146
proteinIdType   UNIPROT
organism        Hsapiens
sequenceCount   12256
bindingSequence <NA>
bindingDomain   Zinc-coordinating
tfFamily        BetaBetaAlpha-zinc finger
experimentType  ChIP-seq
pubmedID        16041365
                 Mmusculus-jaspar2016-Egr1-MA0162.1
providerName    MA0162.1
providerId      MA0162.1
dataSource      jaspar2016
geneSymbol      Egr1
geneId          <NA>
geneIdType      <NA>
proteinId       P08046
proteinIdType   UNIPROT
organism        Mmusculus
sequenceCount   15
bindingSequence <NA>
bindingDomain   <NA>
tfFamily        BetaBetaAlpha-zinc finger
experimentType  bacterial 1-hybrid
pubmedID        24194598
                 Hsapiens-jaspar2016-EGR1-MA0162.2
providerName    MA0162.2
providerId      MA0162.2
dataSource      jaspar2016
geneSymbol      EGR1
geneId          <NA>
geneIdType      <NA>
proteinId       P18146
proteinIdType   UNIPROT
organism        Hsapiens
sequenceCount   12256
bindingSequence <NA>
bindingDomain   <NA>
tfFamily        Three-zinc finger Krüppel-related factors
experimentType  ChIP-seq
pubmedID        24194598
                 Mmusculus-jaspar2018-Egr1-MA0162.1
providerName    MA0162.1
providerId      MA0162.1
dataSource      jaspar2018
geneSymbol      Egr1
geneId          <NA>
geneIdType      <NA>
proteinId       P08046
proteinIdType   UNIPROT
organism        Mmusculus
sequenceCount   15
bindingSequence <NA>
bindingDomain   <NA>
tfFamily        Three-zinc finger Kruppel-related factors
experimentType  bacterial 1-hybrid
pubmedID        16041365
                 Hsapiens-jaspar2018-EGR1-MA0162.2
providerName    MA0162.2
providerId      MA0162.2
dataSource      jaspar2018
geneSymbol      EGR1
geneId          <NA>
geneIdType      <NA>
proteinId       P18146
proteinIdType   UNIPROT
organism        Hsapiens
sequenceCount   12256
bindingSequence <NA>
bindingDomain   <NA>
tfFamily        Three-zinc finger Kruppel-related factors
experimentType  ChIP-seq
pubmedID        16041365
                 Hsapiens-jaspar2018-EGR1-MA0162.3
providerName    MA0162.3
providerId      MA0162.3
dataSource      jaspar2018
geneSymbol      EGR1
geneId          <NA>
geneIdType      <NA>
proteinId       P18146
proteinIdType   UNIPROT
organism        Hsapiens
sequenceCount   2158
bindingSequence <NA>
bindingDomain   <NA>
tfFamily        Three-zinc finger Kruppel-related factors
experimentType  HT-SELEX
pubmedID        16041365
                 Hsapiens-jolma2013-EGR1 Hsapiens-jolma2013-EGR1-2
providerName    Hsapiens-jolma2013-EGR1 Hsapiens-jolma2013-EGR1-2
providerId      EGR1                    EGR1
dataSource      jolma2013               jolma2013
geneSymbol      EGR1                    EGR1
geneId          1958                    1958
geneIdType      ENTREZ                  ENTREZ
proteinId       <NA>                    <NA>
proteinIdType   <NA>                    <NA>
organism        Hsapiens                Hsapiens
sequenceCount   1831                    1703
bindingSequence NMCGCCCMCGCANN          NACGCCCACGCANN
bindingDomain   <NA>                    <NA>
tfFamily        C2H2                    C2H2
experimentType  SELEX                   SELEX
pubmedID        23332764                23332764
                 Mmusculus-jolma2013-Egr1
providerName    Mmusculus-jolma2013-Egr1
providerId      Egr1
dataSource      jolma2013
geneSymbol      Egr1
geneId          1958
geneIdType      ENTREZ
proteinId       <NA>
proteinIdType   <NA>
organism        Mmusculus
sequenceCount   2013
bindingSequence NNMCGCCCMCTCANNN
bindingDomain   <NA>
tfFamily        C2H2
experimentType  SELEX
pubmedID        23332764
                 Hsapiens-SwissRegulon-EGR1.SwissRegulon
providerName    EGR1.SwissRegulon
providerId      EGR1.SwissRegulon
dataSource      SwissRegulon
geneSymbol      EGR1
geneId          <NA>
geneIdType      <NA>
proteinId       <NA>
proteinIdType   UNIPROT
organism        Hsapiens
sequenceCount   15
bindingSequence <NA>
bindingDomain   <NA>
tfFamily        <NA>
experimentType  low- and high-throughput methods
pubmedID        19377474
                 Mmusculus-UniPROBE-Egr1.UP00007
providerName    SCI09/Egr1_pwm_primary.txt
providerId      UP00007
dataSource      UniPROBE
geneSymbol      Egr1
geneId          13653
geneIdType      ENTREZ
proteinId       P08046
proteinIdType   UNIPROT
organism        Mmusculus
sequenceCount   <NA>
bindingSequence <NA>
bindingDomain   ZnF_C2H2
tfFamily        <NA>
experimentType  protein binding microarray
pubmedID        19443739

 > ###################################################
 > ### code chunk number 19: egr1-multi-grep
 > ################################################## .... [TRUNCATED]

 > organism.rows = grep ('Mmusculus', values (MotifDb)$organism, 
ignore.case=TRUE)

 > source.rows = grep ('JASPAR', values (MotifDb)$dataSource, 
ignore.case=TRUE)

 > egr1.mouse.jaspar.rows = intersect (geneSymbol.rows,
+                            intersect (organism.rows, source.rows))

 > print (egr1.mouse.jaspar.rows)
[1] 4246 5400 6521

 > egr1.motif <- MotifDb [egr1.mouse.jaspar.rows]

 > ###################################################
 > ### code chunk number 20: MotifDbViews
 > ###################################################
 > .... [TRUNCATED]

 > ###################################################
 > ### code chunk number 22: examine-egr1
 > ###################################################
 > .... [TRUNCATED]
MotifDb object of length 1
| Created from downloaded public sources: 2013-Aug-30
| 1 position frequency matrices from 1 source:
|        JASPAR_CORE:    1
| 1 organism/s
|          Mmusculus:    1
Mmusculus-JASPAR_CORE-Egr1-MA0162.1

 > as.list (egr1.motif)
$`Mmusculus-JASPAR_CORE-Egr1-MA0162.1`
            1          2         3 4   5   6          7 8         9 10
A 0.20000000 0.13333333 0.0000000 0 0.0 0.2 0.06666667 0 0.1333333  0
C 0.26666667 0.06666667 0.8666667 0 0.0 0.0 0.00000000 0 0.6666667  0
G 0.06666667 0.80000000 0.0000000 1 0.2 0.8 0.93333333 1 0.0000000  1
T 0.46666667 0.00000000 0.1333333 0 0.8 0.0 0.00000000 0 0.2000000  0
           11
A 0.06666667
C 0.00000000
G 0.46666667
T 0.46666667


 > noquote (t (as.data.frame (values (egr1.motif))))
                 Mmusculus-JASPAR_CORE-Egr1-MA0162.1
providerName    Egr1
providerId      MA0162.1
dataSource      JASPAR_CORE
geneSymbol      Egr1
geneId          13653
geneIdType      ENTREZ
proteinId       P08046
proteinIdType   UNIPROT
organism        Mmusculus
sequenceCount   15
bindingSequence <NA>
bindingDomain   Zinc-coordinating
tfFamily        BetaBetaAlpha-zinc finger
experimentType  bacterial 1-hybrid
pubmedID        16041365

 > ###################################################
 > ### code chunk number 23: egr1
 > ###################################################
 > seqLogo .... [TRUNCATED]

 > ###################################################
 > ### code chunk number 24: motifmatch
 > ###################################################
 > e .... [TRUNCATED]

	Ungapped Alignment
	Scores read
	Database read
	Motif matches : 11
*** Error in `/home/hpages/R/R-4.0.r78037/bin/exec/R': double free or 
corruption (out): 0x00000000437ffa80 ***
======= Backtrace: =========
/lib/x86_64-linux-gnu/libc.so.6(+0x777e5)[0x7f8738f287e5]
/lib/x86_64-linux-gnu/libc.so.6(+0x8037a)[0x7f8738f3137a]
/lib/x86_64-linux-gnu/libc.so.6(cfree+0x4c)[0x7f8738f3553c]
/home/hpages/R/R-4.0.r78037/library/MotIV/libs/MotIV.so(_ZN15PlatformSupportD1Ev+0x8c)[0x7f871cc28c2c]
/home/hpages/R/R-4.0.r78037/library/MotIV/libs/MotIV.so(_Z10motifMatchP7SEXPRECS0_S0_S0_S0_S0_S0_S0_+0x31e)[0x7f871cc2623e]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0xfc9d2)[0x7f87395949d2]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0xfceed)[0x7f8739594eed]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x134601)[0x7f87395cc601]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_eval+0x1a0)[0x7f87395dbfd0]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x145d91)[0x7f87395ddd91]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_applyClosure+0x1b4)[0x7f87395deb34]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_eval+0x2ce)[0x7f87395dc0fe]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x1490e9)[0x7f87395e10e9]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_eval+0x53d)[0x7f87395dc36d]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x14a8e3)[0x7f87395e28e3]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x134601)[0x7f87395cc601]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_eval+0x1a0)[0x7f87395dbfd0]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x145d91)[0x7f87395ddd91]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_applyClosure+0x1b4)[0x7f87395deb34]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x13e4f7)[0x7f87395d64f7]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_eval+0x1a0)[0x7f87395dbfd0]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x1449c9)[0x7f87395dc9c9]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_eval+0x818)[0x7f87395dc648]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x14abec)[0x7f87395e2bec]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x18682f)[0x7f873961e82f]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x136175)[0x7f87395ce175]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_eval+0x1a0)[0x7f87395dbfd0]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x145d91)[0x7f87395ddd91]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_applyClosure+0x1b4)[0x7f87395deb34]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x13e4f7)[0x7f87395d64f7]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_eval+0x1a0)[0x7f87395dbfd0]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x145d91)[0x7f87395ddd91]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_applyClosure+0x1b4)[0x7f87395deb34]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_eval+0x2ce)[0x7f87395dc0fe]
/home/hpages/R/R-4.0.r78037/lib/libR.so(Rf_ReplIteration+0x242)[0x7f873960f662]
/home/hpages/R/R-4.0.r78037/lib/libR.so(+0x1779f1)[0x7f873960f9f1]
/home/hpages/R/R-4.0.r78037/lib/libR.so(run_Rmainloop+0x48)[0x7f873960faa8]
/home/hpages/R/R-4.0.r78037/bin/exec/R(main+0x1b)[0x4007cb]
/lib/x86_64-linux-gnu/libc.so.6(__libc_start_main+0xf0)[0x7f8738ed1830]
/home/hpages/R/R-4.0.r78037/bin/exec/R(_start+0x29)[0x400809]
======= Memory map: ========
00400000-00401000 r-xp 00000000 00:33 23419198 
/home/hpages/R/R-4.0.r78037/bin/exec/R
00600000-00601000 r--p 00000000 00:33 23419198 
/home/hpages/R/R-4.0.r78037/bin/exec/R
00601000-00602000 rw-p 00001000 00:33 23419198 
/home/hpages/R/R-4.0.r78037/bin/exec/R
01334000-49409000 rw-p 00000000 00:00 0 
[heap]
7f8710000000-7f8710021000 rw-p 00000000 00:00 0
7f8710021000-7f8714000000 ---p 00000000 00:00 0
7f871709e000-7f871709f000 rw-p 00000000 00:00 0
7f871709f000-7f87170c0000 r--p 00000000 103:02 9972832 
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7f8739d4c000-7f8739d4d000 r--s 00000000 103:02 29494940 
/var/cache/fontconfig/e0aa53bcfa504e64f87823c16bc01eb6-le64.cache-6
7f8739d4d000-7f8739d4e000 r--p 00000000 00:33 23419290 
/home/hpages/R/R-4.0.r78037/library/translations/en/LC_MESSAGES/R.mo
7f8739d4e000-7f8739d55000 r--s 00000000 103:02 10235479 
/usr/lib/x86_64-linux-gnu/gconv/gconv-modules.cache
7f8739d55000-7f8739d56000 rw-p 00000000 00:00 0
7f8739d56000-7f8739d57000 r--p 00025000 103:02 394737 
/lib/x86_64-linux-gnu/ld-2.23.so
7f8739d57000-7f8739d58000 rw-p 00026000 103:02 394737 
/lib/x86_64-linux-gnu/ld-2.23.so
7f8739d58000-7f8739d59000 rw-p 00000000 00:00 0
7ffd424ab000-7ffd42500000 rw-p 00000000 00:00 0 
[stack]
7ffd425c4000-7ffd425c7000 r--p 00000000 00:00 0 
[vvar]
7ffd425c7000-7ffd425c9000 r-xp 00000000 00:00 0 
[vdso]
ffffffffff600000-ffffffffff601000 r-xp 00000000 00:00 0 
[vsyscall]
Aborted (core dumped)
hpages using spectre:~/MotifDb/vignettes$

----------------------------------------------------------------------

On 3/26/20 16:31, Paul Shannon wrote:
> Dear Bioc,
> 
> I have added the lasted HOCOMOCO motifs to MotifDb but changed no code.   The package 1.29.6 dumps core during in the bioc devel linux build, and fails perhaps similarly on windows.
> 
>     https://urldefense.proofpoint.com/v2/url?u=http-3A__bioconductor.org_checkResults_devel_bioc-2DLATEST_MotifDb_malbec2-2Dbuildsrc.html&d=DwIFAg&c=eRAMFD45gAfqt84VtBcfhQ&r=BK7q3XeAvimeWdGbWY_wJYbW0WYiZvSXAJJKaaPhzWA&m=3nyFO44fKEjL0UQgr9v3rdH5xN5N0L-oPwJKqCde-KA&s=39WsjZfDBDIfFAUX64qytpa9HhMcXAg5hSs9bnZWf4A&e=
> 
> Any suggestions on how I can track this down?   The package builds and checks clean on my macOS and linux systems.
> 
>   - Paul
> _______________________________________________
> Bioc-devel using r-project.org mailing list
> https://urldefense.proofpoint.com/v2/url?u=https-3A__stat.ethz.ch_mailman_listinfo_bioc-2Ddevel&d=DwIFAg&c=eRAMFD45gAfqt84VtBcfhQ&r=BK7q3XeAvimeWdGbWY_wJYbW0WYiZvSXAJJKaaPhzWA&m=3nyFO44fKEjL0UQgr9v3rdH5xN5N0L-oPwJKqCde-KA&s=R3gXyvG3OC_JFgAHmeE67RR_NRUmDjW7YGAJb7dIdsA&e=
> 

-- 
Hervé Pagès

Program in Computational Biology
Division of Public Health Sciences
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N, M1-B514
P.O. Box 19024
Seattle, WA 98109-1024

E-mail: hpages using fredhutch.org
Phone:  (206) 667-5791
Fax:    (206) 667-1319



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