[Bioc-devel] Alternative Hypothesis Specification For edgeR

Aaron Lun alun at wehi.edu.au
Wed Jan 18 11:43:05 CET 2017

Hi Dario,

I guess so - it would be a fairly easy extension of glmLRT - but why? I 
can't think of many situations where a non-zero log-fold change is 
expected under the null hypothesis. Mixture experiments, or correcting 
for gene dosage due to copy number variants, perhaps.



On 16/01/17 04:00, Dario Strbenac wrote:
> Good day,
> In a future release, could the user be allowed to specify an alternative hypothesis such as the coefficient being positive? DESeq2 provides an altHypothesis parameter for such a purpose.
> --------------------------------------
> Dario Strbenac
> University of Sydney
> Camperdown NSW 2050
> Australia
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