Pharmacokinetics of Indomethacin

Description

The Indometh data frame has 66 rows and 3 columns of data on the pharmacokinetics of indometacin (or, older spelling, ‘indomethacin’).

Usage

Indometh

Format

An object of class c("nfnGroupedData", "nfGroupedData", "groupedData", "data.frame") containing the following columns:

Subject

an ordered factor with containing the subject codes. The ordering is according to increasing maximum response.

time

a numeric vector of times at which blood samples were drawn (hr).

conc

a numeric vector of plasma concentrations of indometacin (mcg/ml).

Details

Each of the six subjects were given an intravenous injection of indometacin.

This dataset was originally part of package nlme, and that has methods (including for [, as.data.frame, plot and print) for its grouped-data classes.

Source

⁠Kwan, Breault, Umbenhauer, McMahon, and Duggan (1976); ⁠Davidian and Giltinan (1995, page 129); ⁠Pinheiro and Bates (2000)

References

⁠Davidian M, Giltinan DM (1995). Nonlinear Models for Repeated Measurement Data, series Chapman & Hall/CRC Monographs on Statistics & Applied Probability. Taylor & Francis. ISBN 9780412983412.

⁠Kwan KC, Breault GO, Umbenhauer ER, McMahon FG, Duggan DE (1976). “Kinetics of Indomethacin Absorption, Elimination, and Enterohepatic Circulation in Man.” Journal of Pharmacokinetics and Biopharmaceutics, 4(3), 255–280. doi:10.1007/bf01063617.

⁠Pinheiro J, Bates DM (2000). Mixed-Effects Models in S and S-PLUS, series Statistics and Computing. Springer New York. ISBN 9780387989570.

See Also

SSbiexp for models fitted to this dataset.