DNase {datasets} | R Documentation |
Elisa assay of DNase
Description
The DNase
data frame has 176 rows and 3 columns of data
obtained during development of an ELISA assay for the recombinant
protein DNase in rat serum.
Usage
DNase
Format
An object of class
c("nfnGroupedData", "nfGroupedData", "groupedData", "data.frame")
containing the following columns:
Run
-
an ordered factor with levels
10
< ... <3
indicating the assay run. conc
-
a numeric vector giving the known concentration of the protein.
density
-
a numeric vector giving the measured optical density (dimensionless) in the assay. Duplicate optical density measurements were obtained.
Details
This dataset was originally part of package nlme, and that has
methods (including for [
, as.data.frame
, plot
and
print
) for its grouped-data classes.
Source
Davidian M, Giltinan DM (1995).
Nonlinear Models for Repeated Measurement Data, series Chapman & Hall/CRC Monographs on Statistics & Applied Probability.
Taylor & Francis.
ISBN 9780412983412.
(Section 5.2.4, page 134.)
Pinheiro J, Bates DM (2000). Mixed-Effects Models in S and S-PLUS, series Statistics and Computing. Springer New York. ISBN 9780387989570.
Examples
require(stats); require(graphics)
coplot(density ~ conc | Run, data = DNase,
show.given = FALSE, type = "b")
coplot(density ~ log(conc) | Run, data = DNase,
show.given = FALSE, type = "b")
## fit a representative run
fm1 <- nls(density ~ SSlogis( log(conc), Asym, xmid, scal ),
data = DNase, subset = Run == 1)
## compare with a four-parameter logistic
fm2 <- nls(density ~ SSfpl( log(conc), A, B, xmid, scal ),
data = DNase, subset = Run == 1)
summary(fm2)
anova(fm1, fm2)