adaptIVPT: Adaptive Bioequivalence Design for In-Vitro Permeation Tests

Contains functions carrying out adaptive procedures using mixed scaling approach to establish bioequivalence for in-vitro permeation test (IVPT) data. Currently, the package provides procedures based on parallel replicate design and balanced data, according to the U.S. Food and Drug Administration's "Draft Guidance on Acyclovir" <>. Potvin et al. (2008) <doi:10.1002/pst.294> provides the basis for our adaptive design (see Method B). For a comprehensive overview of the method, refer to Lim et al. (2023) <doi:10.1002/pst.2333>. This package reflects the views of the authors and should not be construed to represent the views or policies of the U.S. Food and Drug Administration.

Version: 1.1.0
Depends: R (≥ 3.4)
Imports: Rcpp, rgl
LinkingTo: Rcpp, RcppArmadillo, RcppProgress
Suggests: knitr, rmarkdown
Published: 2024-01-26
DOI: 10.32614/CRAN.package.adaptIVPT
Author: Daeyoung Lim [aut, cre], Elena Rantou [ctb], Jessica Kim [ctb], Sungwoo Choi [ctb], Nam Hee Choi [ctb], Stella Grosser [ctb]
Maintainer: Daeyoung Lim <Daeyoung.Lim at>
License: GPL (≥ 3)
NeedsCompilation: yes
Citation: adaptIVPT citation info
Materials: NEWS
CRAN checks: adaptIVPT results


Reference manual: adaptIVPT.pdf


Package source: adaptIVPT_1.1.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): adaptIVPT_1.1.0.tgz, r-oldrel (arm64): adaptIVPT_1.1.0.tgz, r-release (x86_64): adaptIVPT_1.1.0.tgz, r-oldrel (x86_64): adaptIVPT_1.1.0.tgz
Old sources: adaptIVPT archive


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