ThreeArmedTrials: Design and Analysis of Clinical Non-Inferiority or Superiority Trials with Active and Placebo Control

Design and analyze three-arm non-inferiority or superiority trials which follow a gold-standard design, i.e. trials with an experimental treatment, an active, and a placebo control. Method for the following distributions are implemented: Poisson (Mielke and Munk (2009) <doi:10.48550/arXiv.0912.4169>), negative binomial (Muetze et al. (2016) <doi:10.1002/sim.6738>), normal (Pigeot et al. (2003) <doi:10.1002/sim.1450>; Hasler et al. (2009) <doi:10.1002/sim.3052>), binary (Friede and Kieser (2007) <doi:10.1002/sim.2543>), nonparametric (Muetze et al. (2017) <doi:10.1002/sim.7176>), exponential (Mielke and Munk (2009) <doi:10.48550/arXiv.0912.4169>).

Version: 1.0-4
Depends: R (≥ 3.0.0)
Imports: stats, MASS, methods, numDeriv
Suggests: testthat, knitr, rmarkdown
Published: 2022-12-16
Author: Tobias Mütze ORCID iD [aut, cre], Tim Friede [ctb]
Maintainer: Tobias Mütze <tobias.muetze at>
License: GPL (≥ 3)
NeedsCompilation: yes
Materials: NEWS
In views: CausalInference, ClinicalTrials, ExperimentalDesign
CRAN checks: ThreeArmedTrials results


Reference manual: ThreeArmedTrials.pdf
Vignettes: An introduction to planning and analyzing three-arm trials using the package ThreeArmedTrials


Package source: ThreeArmedTrials_1.0-4.tar.gz
Windows binaries: r-prerel:, r-release:, r-oldrel:
macOS binaries: r-prerel (arm64): ThreeArmedTrials_1.0-4.tgz, r-release (arm64): ThreeArmedTrials_1.0-4.tgz, r-oldrel (arm64): ThreeArmedTrials_1.0-4.tgz, r-prerel (x86_64): ThreeArmedTrials_1.0-4.tgz, r-release (x86_64): ThreeArmedTrials_1.0-4.tgz
Old sources: ThreeArmedTrials archive


Please use the canonical form to link to this page.