MetaEntropy: Functional Shannon Entropy for Virome Mutational Analysis
Estimates Shannon entropy, per gene and per genomic position,
associated with non-synonymous mutation frequencies in viral populations,
such as wastewater samples. The package uses codon translations for
functional insights. Each amino acid can be treated as an individual state,
resulting in a 20-state entropy computation, or grouped into one of six
physicochemical classes, adding further functional context. Provides
normalized values (0-1 scale) to facilitate the direct comparison of
different genomic positions or total functional entropy across multiple
metagenomes. Designed to analyze mutational data using tabular 'Single
Nucleotide Variant' (SNV) frequency tables generated by variant callers
(e.g., 'iVar' or 'LoFreq'), operating independently of consensus sequence
estimation and multiple sequence alignment.
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[aut, cre],
Julieta Marina Manrique