MAPITR: MArginal ePIstasis Test for Regions

A genetic analysis tool and variance component model for identifying marginal epistasis between pathways and the rest of the genome. 'MAPITR' uses as input a matrix of genotypes, a vector of phenotypes, and a list of pathways. 'MAPITR' then iteratively tests each pathway for epistasis between any variants within the pathway versus any variants remaining in the rest of the genome. 'MAPITR' returns results in the form of p-values for every pathway indicating whether the null model of there being no epistatic interactions between a pathway and the rest of the genome can be rejected.

Version: 1.1.2
Depends: R (≥ 3.3.0)
Imports: stats, doParallel, Rcpp (≥ 1.0.5), CompQuadForm
LinkingTo: Rcpp, RcppArmadillo
Suggests: testthat, knitr, rmarkdown
Published: 2020-09-28
DOI: 10.32614/CRAN.package.MAPITR
Author: Michael Turchin ORCID iD [aut, cre], Gregory Darnell ORCID iD [aut, ctb], Lorin Crawford ORCID iD [aut, ctb], Sohini Ramachandran ORCID iD [aut], Peter Carbonetto ORCID iD [ctb]
Maintainer: Michael Turchin <michael_turchin at>
License: MIT + file LICENSE
NeedsCompilation: yes
Materials: README
CRAN checks: MAPITR results


Reference manual: MAPITR.pdf
Vignettes: MAPITR Introduction – Simulated Data


Package source: MAPITR_1.1.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): MAPITR_1.1.2.tgz, r-oldrel (arm64): MAPITR_1.1.2.tgz, r-release (x86_64): MAPITR_1.1.2.tgz, r-oldrel (x86_64): MAPITR_1.1.2.tgz
Old sources: MAPITR archive


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